Anti-KCNA5 antibody

Anti-KCNA5 antibody

Cat. No.     JC220896
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-KCNA5 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Fusion protein of human KCNA5
Reactivity                 Human, Mouse, Rat
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 KCNA5
Full name                 potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms    HK2, HCK1, PCN1, ATFB7, HPCN1, KV1.5
Swissprot    P22460

Target Background
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).

Applications
Western blotting
Predicted band size:67 kDa
Positive control:Mouse spleen tissue 
Recommended dilution: 500-2000