Product overview
Description Anti-PARP1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human PARP1
Reactivity Human, Mouse, Rat
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-PARP1 antibody Target information
Symbol PARP1
Full name poly (ADP-ribose) polymerase 1
Synonyms PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1
Swissprot P09874
Target Background
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Anti-PARP1 antibody Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human liver cancer
Recommended dilution: 25-100 Predicted cell location: Nucleus
Positive control: Human breast cancer
Recommended dilution: 25-100