Anti-GRIA4 antibody

Anti-GRIA4 antibody

Cat. No.     JC264266
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-GRIA4 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human GRIA4
Reactivity                 Human, Mouse, Rat
Content                     1.8 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 GRIA4
Full name                 glutamate ionotropic receptor AMPA type subunit 4
Synonyms    GLUR4; GLURD; GluA4; GLUR4C
Swissprot    P48058

Target Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

Applications
Immunohistochemistry
Predicted cell location: Cell membrane
Positive control: Human tonsil
Recommended dilution: 50-300    
            
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml264266(GRIA4 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)    

ELISA
Recommended dilution: 5000-10000