Product overview
Description Anti-ROR1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human ROR1
Reactivity Human, Mouse
Content 0.9 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ROR1
Full name receptor tyrosine kinase-like orphan receptor 1
Synonyms NTRKR1; dJ537F10.1
Swissprot Q01973
Target Background
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.