Product overview
Description Anti-SLC39A3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human SLC39A3
Reactivity Human, Mouse, Rat
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol SLC39A3
Full name solute carrier family 39 (zinc transporter), member 3
Synonyms ZIP3; ZIP-3
Swissprot Q9BRY0
Target Background
SLC39A3 (solute carrier family 39, member 2), is a 314 amino acid acid multi-pass membrane protein that localizes to the cell membrane and belongs to the ZIP family of zinc transporters. Two isoforms of ZIP3 exist as a result of alternative splicing events. ZIP3 is involved in translocation of extracellular zinc into a variety of cell types. Tumorigenic prostate epithelial cells contain less intracellular zinc than non-tumorigenic prostate epithelial cells. Loss of the ability to maintain zinc accumulation may be caused by the decrease in the ZIP1 protein expression and the intracellular redistribution of ZIP3.