Product overview
Description Anti-FANCE rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human FANCE
Reactivity Human
Content 1.92 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol FANCE
Full name Fanconi anemia complementation group E
Synonyms FAE; FACE
Swissprot Q9HB96
Target Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E.
Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human cervical cancer
Recommended dilution: 50-300 Predicted cell location: Nucleus
Positive control: Human thyroid cancer
Recommended dilution: 50-300
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ml263886(FANCE Antibody) at dilution 1/65, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml263886(FANCE Antibody) at dilution 1/65, on the right is treated with synthetic peptide. (Original magnification: ×200)