Product overview
Description Anti-ETAA1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human ETAA1
Reactivity Human
Content 1.14 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ETAA1
Full name ETAA1, ATR kinase activator
Synonyms ETAA16
Swissprot Q9NY74
Target Background
ETAA1 (Ewing's tumor-associated antigen 1), also known as ETAA16, is a 926 amino acid cytoplasmic protein that is highly expressed in kidney, brain, liver and Ewing tumor cell lines. ETAA1 undergoes post-translational phosphorylation following DNA damage, most likely by either ATM or ATR, and is suggested to function as a tumour-specific cell surface antigen in Ewing's family of tumour cell lines. The gene encoding ETAA1 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstrom syndrome.
Applications
Immunohistochemistry
Predicted cell location: Cell membrane
Positive control: Human esophagus cancer
Recommended dilution: 40-200 Predicted cell location: Cell membrane
Positive control: Human breast cancer
Recommended dilution: 40-200
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml263834(ETAA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using ml263834(ETAA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)