Anti-CYP2C8 antibody

Anti-CYP2C8 antibody

Cat. No.     JC263654
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CYP2C8 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human CYP2C8
Reactivity                 Human
Content                     0.54 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CYP2C8
Full name                 cytochrome P450 family 2 subfamily C member 8
Synonyms    CPC8; CYPIIC8; MP-12/MP-20
Swissprot    P10632

Target Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Cell membrane
Positive control: Human liver cancer
Recommended dilution: 20-100    Predicted cell location: Cytoplasm or Cell membrane
Positive control: Human gastric cancer
Recommended dilution: 20-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml263654(CYP2C8 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ml263654(CYP2C8 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 500-1000