Product overview
Description Anti-BRAF rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human BRAF
Reactivity Human, Mouse
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-BRAF antibody Target information
Symbol BRAF
Full name v-raf murine sarcoma viral oncogene homolog B
Synonyms NS7; BRAF1; RAFB1; B-RAF1
Swissprot P15056
Target Background
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
Anti-BRAF antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human cervical cancer
Recommended dilution: 50-200 Predicted cell location: Cytoplasm and Nucleus
Positive control: Human prostate cancer
Recommended dilution: 50-200