Product overview
Description Anti-NELFB rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human NELFB
Reactivity Human, Mouse
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol NELFB
Full name negative elongation factor complex member B
Synonyms COBRA1; NELF-B
Swissprot Q8WX92
Target Background
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
Applications
Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human ovarian cancer
Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using ml263488(NELFB Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)