Product overview
Description Anti-LRP8 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human LRP8
Reactivity Human, Mouse
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol LRP8
Full name low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms MCI1; LRP-8; APOER2; HSZ75190
Swissprot Q14114
Target Background
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.