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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 靶点:
详见说明书
- 级别:
1
- 目录编号:
LM-10373R-FITC
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
Anti-Phospho-Glycogen synthase 1(Ser640)/FITC
- 抗体名:
Anti-Phospho-Glycogen synthase 1(Ser640)/FITC
- 标记物:
FITC标记
- 宿主:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Cat,
- 适应物种:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Cat,
- 免疫原:
详见说明书
- 亚型:
IGg
- 形态:
粉末、液体、冻干粉
- 应用范围:
ICC=1:50-200 IF=1:50-200
- 浓度:
1mg/ml
- 保存条件:
-20 °C
- 规格:
100ul
| 英文名称 | Anti-Phospho-Glycogen synthase 1(Ser640)/FITC |
| 中文名称 | FITC标记的磷酸化葡萄糖合成酶1抗体 |
| 别 名 | Glycogen synthase 1 (phospho S640); Glycogen synthase 1 (phospho Ser640); p-Glycogen synthase 1 (S640); Glycogen synthase 1 (muscle); Glycogen synthase 1; GSY; GYS; GYS1; EC 2.4.1.11; Glycogen synthase1; GYS 1; Starchsynthase muscle; UDP glucose glycogen glucosyltransferase; GYS1_HUMAN; Glycogen [starch] synthase, muscl. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 生长因子和激素 转录调节因子 糖尿病 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Cat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Ser640 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70% identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation. Function: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Subunit: Interacts with GYG1. Post-translational modifications: Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme. DISEASE: Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. Similarity: Belongs to the glycosyltransferase 3 family. Database links: UniProtKB/Swiss-Prot: P13807.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验内腔可产生高强度的磁场,足以分离磁微粒标记的细胞,无需分离柱提供提供更高强度的磁场。由于磁微粒极小,不会影响靶细胞的流式分析结果,因此不需要去除。除了现有的定型产品外,客户可选择EasySep® PE、FITC或生物素分选系统与自己的PE、FITC或生物素—偶联的单抗相结合,来富集任何所需的细胞。如果您有自己的小鼠IgG1抗任何细胞的抗体, 也可以使用“Do-It-Yourself”试剂盒做成TAC,用来分选您想要的细胞。此外,还可以根据您的特殊需要,专门为您设计定做试剂盒。用于正选小鼠的细胞标记
打破传统认知,降糖不仅依赖胰岛素!科学家发现,这种来自脂肪的激素也可以调节血糖……
%,但对 adR1KO 小鼠无影响。 放射标记的油酸是体内脂肪分解的一种测量方法,他们的实验发现,在 FGF1 处理的 adR1WT 小鼠中,油酸的转换率降低,表明基础脂解降低。相比之下,FGF1 预处理对 adR1KO 小鼠的油酸转换率没有影响。因此,上述的发现表明 FGF1-FGFR1 信号通路是一种调节脂肪分解的新途径。 图片来源:Cell Metabolism FGF1 调节体内肝脏葡萄糖生成 胰岛素在一定程度上通过抑制脂解从而抑制肝脏葡萄糖生成(HGP)来调节血糖水平,而 HGP 的异常
指生物体内由葡萄糖等单糖合成糖原的过程。为糖原分解的逆过程。将更普遍的用低分子的乳糖等通过糖酵解的逆过程而生成糖原的过程称糖异生以资与之区别。动物主要在肝脏或肌肉中进行,为能源储藏的一个主要过程。食物消化后由消化器官吸入血液中的葡萄糖,通过肝门脉而运到肝脏,在那里在已糖激酶和 ATP的作用下先磷酸化成 6-磷酸葡萄糖,再经 1-磷酸葡萄糖而成 UDP葡萄糖,再在糖原合成酶的作用下生成糖原。此时形成α- 1, 4-糖苷键,但其α- 1, 6键由称为脱支酶的一种转糖苷酶的协同
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