Product overview
Description Anti-TEK rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human TEK
Reactivity Human, Mouse
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol TEK
Full name TEK tyrosine kinase, endothelial
Synonyms TIE2; VMCM; TIE-2; VMCM1; CD202B
Swissprot Q02763
Target Background
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.