Product overview
Description Anti-ORAI1(L2) rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human ORAI1(L2)
Reactivity Human
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ORAI1
Full name ORAI calcium release-activated calcium modulator 1
Synonyms IMD9; TAM2; ORAT1; CRACM1; TMEM142A
Swissprot Q96D31
Target Background
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).