Anti-ADAMTS8 antibody

Anti-ADAMTS8 antibody

Cat. No.     JC262833
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-ADAMTS8 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human ADAMTS8
Reactivity                 Human, Mouse
Content                     1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 ADAMTS8
Full name                 ADAM metallopeptidase with thrombospondin type 1 motif, 8
Synonyms    METH2; ADAM-TS8
Swissprot    Q9UP79

Target Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

Applications
Immunohistochemistry
Predicted cell location: Secreted
Positive control: Human liver cancer
Recommended dilution: 20-100    
            
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml262833(ADAMTS8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)    

ELISA
Recommended dilution: 5000-10000