Product overview
Description Anti-EML4 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human EML4
Reactivity Human
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol EML4
Full name echinoderm microtubule associated protein like 4
Synonyms C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120
Swissprot Q9HC35
Target Background
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human gastric cancer
Recommended dilution: 25-100 Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human esophagus cancer
Recommended dilution: 25-100
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ml262773(EML4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using ml262773(EML4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)