Anti-COX8C antibody

Anti-COX8C antibody

Cat. No.     JC262762
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-COX8C rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human COX8C
Reactivity                 Human
Content                     0.7 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 COX8C
Full name                 cytochrome c oxidase subunit VIIIC
Synonyms    COX8-3
Swissprot    Q7Z4L0

Target Background
The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water and ATP. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. The COX8 (cytochrome c oxidase subunit VIII) subunits are nuclear and have muscle and non-muscle-specific isoforms. COX8 exists as three isoforms: COX8a, a liver and heart isoform, Cox8b, a heart-specific isoform, and Cox8c, whose expression pattern has yet to be elucidated. All three Cox8 isoforms exists as components of the COX complex and play an important role in electron transport. This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human prostate cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm
Positive control: Human tonsil
Recommended dilution: 25-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using ml262762(COX8C Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using ml262762(COX8C Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 2000-5000