Product overview
Description Anti-CXCR3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human CXCR3
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CXCR3
Full name chemokine (C-X-C motif) receptor 3
Synonyms GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R
Swissprot P49682
Target Background
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.