Anti-SLC7A11 antibody

Anti-SLC7A11 antibody

Cat. No.     JC262619
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-SLC7A11 rabbit polyclonal antibody
Applications        ELISA, WB, IHC 
Immunogen               Synthetic peptide of human SLC7A11
Reactivity                 Human, Mouse
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 SLC7A11
Full name                 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Synonyms    xCT; CCBR1
Swissprot    Q9UPY5

Target Background
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Applications
Immunohistochemistry
Predicted cell location: Cell membrane
Positive control: Human brain
Recommended dilution: 20-100    Predicted cell location: Cell membrane
Positive control: Human thyroid cancer
Recommended dilution: 20-100
            
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ml262619(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml262619(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
Western blotting
Predicted band size:55 kDa
Positive control:K562 and hepg2 cell 
Recommended dilution: 500-2000