- 询价
- gelatins
- JC124644
- 进口/国产
- 2025年07月12日
- ELISA, WB
- Rabbit
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海机纯实业有限公司
- 库存：
大量
- 克隆性：
多克隆
- 保质期：
12个月
- 抗体英文名：
Anti-WWTR1 antibody
- 宿主：
Rabbit
- 适应物种：
人/动物/植物
- 应用范围：
ELISA, WB
- 浓度：
0.8 mg/ml
- 保存条件：
-20°C
- 规格：
25 μl/100 μl/200 μl
Cat. No. JC124644
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-WWTR1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human WWTR1
Reactivity Human, Mouse
Content 0.8 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-WWTR1 antibody
Target information
Symbol WWTR1
Full name WW domain containing transcription regulator 1
Synonyms TAZ
Swissprot Q9GZV5
Target Background
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Anti-WWTR1 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human liver cancer
Recommended dilution: 25-100 Predicted cell location: Cytoplasm or Nucleus
Positive control: Human lung cancer
Recommended dilution: 25-100
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