Product overview
Description Anti-IAPP rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human IAPP
Reactivity Human, Mouse, Rat
Content 0.8 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol IAPP
Full name islet amyloid polypeptide
Synonyms DAP; IAP
Swissprot P10997
Target Background
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.