Anti-RIC8A antibody

Anti-RIC8A antibody

Cat. No.     JK125863  
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-RIC8A rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human RIC8A
Reactivity                 Human, Mouse, Rat
Content                     1.44 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification


Target information
Symbol                 RIC8A
Full name                 RIC8 guanine nucleotide exchange factor A
Synonyms    RIC8
Swissprot    Q9NPQ8

Target Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.