- 询价
- Signalway Antibody
- USA
- AP79376
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Low-density lipoprotein receptor-related protein 5
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:LR3,LRP7
accession_no:O75197
Gene name:LRP5
calculated_mw:
tag info:His
Immunogen Description:CARQQAFRNKTVTADNTLH
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction (PubMed:27228167). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation.
产品详细信息请点击：Low-density lipoprotein receptor-related protein 5
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文献和实验Assessment of Susceptibility of Low-Density Lipoprotein to Oxidation
It is now recognized that oxidation of low-density lipoprotein (LDL) is a key event in the development of atherosclerosis (1 ). In vivo, oxidation is believed to occur primarily in the arterial wall. In early atherosclerotic lesions
Interactions of Lipid-Oligonucleotide Conjugates with Low-Density Lipoprotein
a variety of non-antisense effects (4 ). Oligonucleotide analogs that do not bind to proteins are therefore expected to display less nonantisense side effects. However, protein binding also affects the in vivo disposition of oligonucleotides
Lipoprotein Isolation - First week
% solution. This is over layered with phosphate buffered saline (PBS), and centrifuged to form a density gradient. Eventually, all proteins float or sink to the zone that corresponds to their density. Having a lower density, the yellow colored lipoprotein
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