- 询价
- Signalway Antibody
- USA
- AP79137
- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Palmitoleoyl-protein carboxylesterase NOTUM
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:OK/SW-CL.30,hNOTUM
accession_no:Q6P988
Gene name:NOTUM
calculated_mw:
tag info:His
Immunogen Description:Recombinant protein
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
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文献和实验Nature 三连发：竞争消除，有你没我，论癌细胞的「霸道行为」
2Onco 系统，Red2Onco 能够使得癌基因在红色荧光蛋白 (Red Fluorescent Protein, RFP+) 标记的克隆中特异性共表达。 图片来源: Nature接下来，研究人员借助 Red2Onco 系统研究了肠道干细胞中的突变克隆是否影响相邻隐窝中野生型克隆的命运。结果发现，突变细胞能够介导野生型细胞动力学的变化，同时，接近突变隐窝的野生型克隆显示出加速漂移，大大超过远端野生型隐窝。 图片来源: Nature随后，为了明确突变克隆是对野生型克隆串扰的机制，他们利用 Red
A Methodology for Detection and Quantification of Esterase Activity
Carboxylesterases are important enzymes for xenobiotic metabolism and are receiving increasing attention in the context of cancer therapies. Quantification of individual carboxylesterase activity is important since protein
-Jun Park, Soo Young Choi, and Hee-Bong Lee(2006)A carboxylesterase from the thermoacidophilic archaeon Sulfolobus solfataricus P1; purification, characterization, and expression.Biochimica et Biophysica (BBA) - General Subjects 1760(5):820-828.Andrey
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