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- Signalway Antibody
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- AP79467
- 2025年06月30日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Major prion protein
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 95% by SDS-PAGE
specificity:Human
other_names:ALTPRP,PRIP,PRP,ASCR,PrP27-30,PrP33-35C,CD230
accession_no:P04156
Gene name:PRNP
calculated_mw:9.68
tag info:His
Immunogen Description:23-110aa
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
产品详细信息请点击：Major prion protein
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文献和实验Secondary structure of prion mRNA
and was confirmed. The third example is the prion-protein mRNA from different organisms; the structure of this mRNA is not known. By application of the algorithm highly conserved hairpins were found in the prion-protein mRNA. Introduction Abbreviations used: bp
A Function for the Prion Protein
opportunities to consider protein function in relation to the disease phenotype arose (5 ). The identification of the prion gene on chromosome 2 of the mouse (chromosome 20 in the human) (6 ), and the determination of its sequence (7 ), led to the translation
Prion Protein as Copper-Binding Protein at the Synapse
Various approaches have been taken to study the function of prion proteins. Biochemical methods were applied to search for a binding partner of PrPC which is attached to the cell surface by a glycosylphosphatidylinositol GPI anchor
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