Chitinase-3-like protein 1

host_species:E.coli

purification:>90% by SDS-PAGE

specificity:Bovine

other_names:39 kDa whey protein,Cartilage glycoprotein 39,Chitinase-like protein 1,SPC-40,Signal-processing protein,CGP-39,CLP-1

accession_no:P30922
Gene name:CHI3L1

calculated_mw:

tag info:His

Immunogen Description:Recombinant protein

formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

background:Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

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