- 询价
- Signalway Antibody
- USA
- AP78976
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
IgG receptor FcRn large subunit p51
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:FCRN,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor
accession_no:P55899
Gene name:FCGRT
calculated_mw:30.14
tag info:His
Immunogen Description:24-297AA
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:
Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).
产品详细信息请点击：IgG receptor FcRn large subunit p51
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文献和实验Methods to Engineer and Identify IgG1 Variants with Improved FcRn Binding or Effector Function
site comprised of the heavy and light chain variable domains. In addition, the Fc portion of human or humanized IgG1 antibodies promotes long half-life through interaction with the recycling FcRn receptor and effects killing functions
Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
class I family Fc receptor, FcRn. We describe human FcRn transgenic mouse models and how they can be exploited productively for the preclinical pharmacokinetic evaluation of therapeutic antibodies.
Gene Therapy with Plasmids Encoding Cytokine- or Cytokine Receptor-IgG Chimeric Proteins
cytokines (1 ). However, cytokine and soluble cytokine-receptor therapy have been limited by the short half-life (T1/2) of these proteins and the necessity to administer relatively large boluses of recombinant proteins (2 ). This results in transient high
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