- 询价
- Signalway Antibody
- USA
- AP78944
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Phorbol-12-myristate-13-acetate-induced protein 1
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 95% by SDS-PAGE
specificity:Human
other_names:NOXA,Immediate-early-response protein APR,Protein Noxa
accession_no:Q13794
Gene name:PMAIP1
calculated_mw:14.96
tag info:His
Immunogen Description:1-136AA
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
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文献和实验Analysis of Protein Kinase C Function
as the major receptor by which the tumor-promoting phorbol esters, such as 4-β-phorbol-12,13-dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA), mediate their many effects on cells, and it has been demonstrated that these molecules can substitute for DG
Protein Kinase C as a Modulator of 5- HT1A and Dopamine- D2 Receptor Signaling
, 1995 ), its translocation to the membrane (Kiley et al., 1995 ), and the phosphorylation of numerous proteins. With the finding by Castagna et al. (1982) that phorbol esters (e.g., 12-O-tetrade-canoyl 4β-phorbol 13-acetate [TPA]) are potent
Protein Kinase C: Measurement of Translocation, Activation, and Role in Cellular Responses
PKC (nPKC) enzymes (δ, ɛ,ζ, η,and θ) are Ca2+ -independent, whereas members of the atypical PKCs (aPKC), ζ and λ, lack the binding site for DAG. Phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), also bind to and activate those enzyme
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