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- Signalway Antibody
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- AP78873
- 2025年07月03日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Transient receptor potential cation channel subfamily V member 1
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:VR1,Capsaicin receptor,Osm-9-like TRP channel 1,Vanilloid receptor 1,OTRPC1
accession_no:Q8NER1
Gene name:TRPV1
calculated_mw:
tag info:His
Immunogen Description:Recombinant protein
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
产品详细信息请点击：Transient receptor potential cation channel subfamily V member 1
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文献和实验to be essential for many biological functions including fluid and enzyme secretion, immune regulation, hypertension, pulmonary function, neurosecretion, synaptic plasticity, and vascular diseases. Canonical transient receptor potential (TRPCs) have been proposed
TRPM2 Function and Potential as a Drug Target
The TRPM subfamily of transient receptor potential channels includes a number of members which are involved in cell proliferation or cell survival. TRPM2, the second member to be cloned, has a key role in the response to oxidative stress
TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation
, the latter influential in the discovery of TRPM8, the first TRP channel shown to be responsive to cold temperatures. TRPM8, a member of the melastatin TRP channel subfamily, is a receptor for a number of cold mimetics such as menthol and icilin, and is activated
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