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- Signalway Antibody
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- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Nitric oxide synthase, inducible
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Mouse
other_names:Inosl,Inducible NO synthase,Macrophage NOS,NOS type II,Peptidyl-cysteine S-nitrosylase NOS2,Inducible NOS,MAC-NOS
accession_no:P29477
Gene name:Nos2
calculated_mw:3.52
tag info:His
Immunogen Description:617-648AA
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7503239). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (PubMed:16373578). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.
产品详细信息请点击：Nitric oxide synthase, inducible
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文献和实验Purification of the Inducible Nitric Oxide Synthase
Regulation of the inducible nitiric oxide synthase (iNOS) isozyme is distinct from the constitutively expressed endothelial (e) and neuronal (n) NOS isozymes in that it occurs at the level of gene expression and not by Ca+2 /calmodulin (CaM
Cloning and Expression of Human Inducible Nitric Oxide Synthase
Much of the excitement over nitric oxide (NO) is owing to its diverse physiologic and pathophysiologic functions. Induced NO production has been shown to have both beneficial and detrimental consequences. The inducible or high-output
Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. The physiological involvement of NO in neuronal transmission, control of vascular tone, and immune response-induced cytostasis
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