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- Signalway Antibody
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- AP78483
- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Heterogeneous nuclear ribonucleoprotein K
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:HNRPK,Transformation up-regulated nuclear protein,TUNP
accession_no:P61978
Gene name:HNRNPK
calculated_mw:17.93
tag info:His
Immunogen Description:35-197AA
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
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文献和实验Preparation of Heterogeneous Nuclear Ribonucleoprotein Complexes
class of nuclear pre-mRNA/mRNA-binding proteins, the heterogeneous nuclear ribonucleoproteins (hnRNPs), to form hnRNP complexes (1 ,2 ). The molecular architecture of these complexes must be exceedingly dynamic because each step in the pre-mRNA
hnRNA heterogeneous nuclear RNA
hnRNA系 heterogeneous nuclear之缩写。为存在于真核生物细胞核中的不稳定、大小不均的一组高分子 RNA（分子量约为 105 ～ 2× 107 ，沉降系数约为 30— 100S）之总称。占细胞全部 RNA之百分之几，在核内主要存在于核仁的外侧。认为 hnRNA多属信使 RNA（ messenger ribonucleic acid， mRNA）之先驱体，包括各种基因的转录产物及其成为 mRNA前的各中间阶段的分子，在 5’末端多附有间隙结构，而 3’的末端附有
Purification of U Small Nuclear Ribonucleoprotein Particles
The spliceosome is the catalytic entity that removes the introns from the primary transcripts in eukaryotes. The spliceosome consists of four small nuclear ribonucleoproteins (snRNPs), named U1,U2, U4/U6, and U5 snRNP, and numerous non-snRNP
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