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- Signalway Antibody
- USA
- AP76568
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Human Tumor necrosis factor(TNF),partial
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:Greater than 90% as determined by SDS-PAGE.
other_names:Cachectin;TNF-alphaTumor necrosis factor ligand superfamily member 2 ;TNF-a
accession_no:P01375
calculated_mw:21.4 kDa
tag info:N-terminal 6xHis-tagged
Immunogen Description:Expression Region:77-233
Sequence Info:Partial
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Cytokine that binds to TNFRSF1A,TNFR1 and TNFRSF1B,TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective .
产品详细信息请点击：Recombinant Human Tumor necrosis factor(TNF),partial
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文献和实验Typing of Tumor Necrosis Factor Alleles
The tumor necrosis factor (TNF) locus contains the three closely related cytokine genes: TNF , and lymphotoxin α and �. The gene cluster lies at the telomeric end of the class III region of the major histocompatibility complex (MHC
Measurement of Tumor Necrosis Factor (TNF) Lysis of Adenovirus-Infected Cells
and specific responses to meet this objective. Virus-infected cells are lysed by cells of the innate immune response such as activated macrophages and natural killer cells, and by cytokines like tumor necrosis factor (TNF) (1 ,2 ). Here, we will discuss
Tumor Necrosis Factor as a Pharmacological Target
Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties released by macrophages stimulated with bacterial products. Almost at the same time that TNF was cloned, it was found to be identical to cachectin
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