Product overview Description Anti-CISH rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Fusion protein of human CISH
Reactivity Human, Mouse, Rat
Content 0.4 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol CISH
Full name cytokine inducible SH2-containing protein
Synonyms CIS; G18; SOCS; CIS-1; BACTS2
Swissprot Q9NSE2
Target Background The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human tonsil
Recommended dilution: 25-100 Predicted cell location: Cytoplasm and Nucleus
Positive control: Human breast cancer
Recommended dilution: 25-100