Anti-EDARADD antibody

Anti-EDARADD antibody

Cat. No.     JC123818        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-EDARADD rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Full length fusion protein
Reactivity                 Human
Content                     0.9 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-EDARADD antibody
Target information
Symbol                 EDARADD
Full name                 EDAR-associated death domain
Synonyms    ED3; EDA3; ECTD11A; ECTD11B
Swissprot    Q8WWZ3

Target Background
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Anti-EDARADD antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human tonsil
Recommended dilution: 35-200