一种有效的PARP1和PARP2抑制剂,Ki分别为5.2nM和2.9nM。ABT888 has been shown to inhibit PARP-1 and PARP-2, enzymes which catalyze the addition of ADP-ribose units to proteins that mediate DNA repair pathways. PARP is also important in initiating apoptosis, and thus inhibition of these enzymes reduces the rate of apoptosis in DNA-damaged cells。