Product overview Description Anti-SGCA rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human SGCA Reactivity Human, Mouse Content 1.2 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol SGCA Full name sarcoglycan alpha Synonyms ADL; DAG2; 50DAG; DMDA2; LGMD2D; SCARMD1; adhalin Swissprot Q16586
Target Background This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.