Anti-CD40 antibody

Anti-CD40 antibody

Cat. No.     JC261532
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CD40 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human CD40
Reactivity                 Human, Mouse
Content                     1.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CD40
Full name                 CD40 molecule, TNF receptor superfamily member 5
Synonyms    p50; Bp50; CDW40; TNFRSF5
Swissprot    P25942

Target Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 100-300    Predicted cell location: Cytoplasm
Positive control: Human gastric cancer
Recommended dilution: 100-300
            
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml261532(CD40 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ml261532(CD40 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 2000-10000