Product overview Description Anti-STRADA rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Full length fusion protein
Reactivity Human, Mouse, Rat
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol STRADA
Full name STE20-related kinase adaptor alpha
Synonyms LYK5; PMSE; Stlk; STRAD; NY-BR-96
Swissprot Q7RTN6
Target Background The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
Applications Immunohistochemistry
Predicted cell location: Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 30-150 Predicted cell location: Nucleus
Positive control: Human gastric cancer
Recommended dilution: 30-150