Product overview
Description Anti-ASCC2 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Synthetic peptide of human ASCC2
Reactivity Human, Mouse
Content 0.7 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ASCC2
Full name activating signal cointegrator 1 complex subunit 2
Synonyms p100; ASC1p100
Swissprot Q9H1I8
Target Background
ASCC2 (activating signal cointegrator 1 complex subunit 2), also known as ASC1P100, is a 757 amino acid protein that is ubiquitously expressed and contains one CUE domain. The gene encoding ASCC2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Applications
Western blotting
Predicted band size:86 kDa
Positive control:A431, 293T and hela cells
Recommended dilution: 500-2000