Anti-TRPC6 antibody

Anti-TRPC6 antibody

Cat. No.     JC261186
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TRPC6 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human TRPC6
Reactivity                 Human
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 TRPC6
Full name                 transient receptor potential cation channel, subfamily C, member 6
Synonyms    TRP6; FSGS2
Swissprot    Q9Y210

Target Background
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-200    Predicted cell location: Cytoplasm
Positive control: Human lung cancer
Recommended dilution: 50-200
            
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml261186(TRPC6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using ml261186(TRPC6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 3000-10000