Product overview
Description Anti-TIGAR rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human TIGAR
Reactivity Human
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol TIGAR
Full name TP53 induced glycolysis regulatory phosphatase
Synonyms FR2BP; C12orf5
Swissprot Q9NQ88
Target Background
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.