品牌:miltenyi,产品名称:Anti-c-Rel-PE, mouse 60 tests Anti-c-Rel antibodies, mouse - Miltenyi Biotec 货号:130-106-187 Clone REA397 recognizes the mouse c-Rel antigen, a 65 kDa member of the NF-κB family of eukaryotic transcription factors, which also includes the proteins RelA (p65), RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB transcription factors can form various homo- and heterodimers possessing unique specificities in regulating target gene expression. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T cell lymphocytes, certain genes essential for immune function such as Il-2 and FoxP3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells controls a delicate balance between tolerance and immunity. Additional information: Clone REA397 displays negligible binding to Fc receptors.