CD307e (FCRL5)-Biotin/CD307e (FcRL5) antibodies, human
库存:
大量
供应商:
科敏商城
CAS号:
130-105-993
品牌:miltenyi,产品名称:CD307e (FCRL5)-Biotin, human CD307e (FcRL5) antibodies, human - Miltenyi Biotec 货号:130-105-993 Clone REA391 recognizes the human CD307e antigen, a 106 kD single-pass type I membrane protein also known as Fc receptor-like protein 5 (FcRL5) or immune receptor translocation-associated protein 2 (IRTA2). CD307e possesses a cytoplasmic tail with inhibitory ITIM phosphorylation signaling motifs. CD307e was found to inhibit B cell antigen receptor signaling by recruiting SHP1 to two ITIM motifs upon B cell antigen receptor co-stimulation, resulting in diminished calcium influx and protein tyrosine phosphorylation. Co-stimulation of CD307e and the B cell antigen receptor promotes proliferation and differentiation of naive B cells. CD307e is expressed on both mature B cells and plasma cells, and is induced by EBV proteins. It is overexpressed on malignant B cells of hairy cell leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and multiple myeloma patients. In addition, serum levels of soluble CD307e are elevated in patients with several types of B cell tumors. Additional information: Clone REA391 displays negligible binding to Fc receptors.