aIL-12(REA121)(P35/P70)-Biotin/Anti-IL-12 (p35/p70) antibodies, human
库存:
大量
供应商:
科敏商城
CAS号:
130-103-769
品牌:miltenyi,产品名称:aIL-12(REA121)(P35/P70)-Biotin,h 30tests Anti-IL-12 (p35/p70) antibodies, human - Miltenyi Biotec 货号:130-103-769 Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages as well as dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity: It induces the production of IFN-γ alone or in synergy with IL-2, is a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Th1)-specific immune responses by promoting the differentiation of CD4+ cells towards a Th1 phenotype while inhibiting the production of Th2 cells. The antibody clone REA121 reacts with the p35 kDa chain and the p70 kDa heterodimer of human IL-12, but not with IL-12-p40. It recognizes the same epitope as clone B-T21. Additional information: Clone REA121 displays negligible binding to Fc receptors.