品牌:miltenyi,产品名称:CD185 (CXCR5)-PE-Vio770, mouse 200 tests CD185 (CXCR5) antibodies, mouse - Miltenyi Biotec 货号:130-102-166 Clone REA215 recognizes murine CD185, which is a 42 kDa multipass chemokine receptor, also known as CXCR5 or BLR (burkitt lymphoma receptor-1). Expression of CD185 is found on mature recirculating B cells, a small subset of CD4+ and CD8+ T cells, and skin-derived migratory dendritic cells. CXCR5 recognizes B cell–attracting chemokine 1 (BCA-1)/ CXCL13 as ligand, which is a homeostatic chemokine, constitutively secreted by stromal cells in B cell areas of secondary lymphoid tissues (follicles). CXCR5 is involved in recruitment of circulating naive B cells to follicles and trafficking and homing of B1 B cells. Mice lacking CXCR5 gene display defective primary follicles and germinal centers formation in the spleen and Peyer patches, and lack inguinal lymph nodes. Additional information: Clone REA215 displays negligible binding to Fc receptors.