Product overview
Description Anti-PARP11 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human PARP11
Reactivity Human, Mouse
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol PARP11
Full name poly (ADP-ribose) polymerase family, member 11
Synonyms ARTD11; MIB006; C12orf6
Swissprot Q9NR21
Target Background
Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein.