Product overview
Description Anti-OS9 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Fusion protein of human OS9
Reactivity Human, Mouse
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol OS9
Full name osteosarcoma amplified 9, endoplasmic reticulum lectin
Synonyms OS-9; ERLEC2
Swissprot Q13438
Target Background
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.