Anti-BRCC3 antibody

Anti-BRCC3 antibody

Cat. No.    JC121996        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-BRCC3 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Fusion protein of human BRCC3
Reactivity                 Human
Content                     0.96 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-BRCC3 antibody
Target information
Symbol                 BRCC3
Full name                 BRCA1/BRCA2-containing complex subunit 3
Synonyms    C6.1A; BRCC36; CXorf53
Swissprot    P46736

Target Background
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Anti-BRCC3 antibody
Applications
Western blotting
Predicted band size:36 kDa
Positive control:Human heart tissue and A549 cell lysates 
Recommended dilution: 200-1000