- 询价
- gelatins
- JLC220548
- 上海
- 2025年07月11日
- 人/动物/植物
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- 详细信息
- 文献和实验
- 技术资料
- 克隆性：
多克隆
- 抗体名：
Anti-DTX3L antibody
- 适应物种：
人/动物/植物
- 浓度：
0.5 mg/ml
- 保存条件：
-20°C
- 规格：
25 μl/100 μl/200 μl
Cat. No. JLC220548
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overview
Description Anti-DTX3L rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Fusion protein of human DTX3L
Reactivity Human
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol DTX3L
Full name deltex 3 like, E3 ubiquitin ligase
Synonyms BBAP
Swissprot Q8TDB6
Target Background
The Deltex family is responsible for influencing Notch signaling and may regulate transcription through interactions with specific transcription factors. Deltex proteins have a basic N-terminus, a central proline-rich region and a C-terminal RING-type zinc finger domain, a motif often found in ubiquitin-protein isopeptide ligases (E3). The RING-type zinc finger domain binds two Zn2+ atoms and forms a cross-brace motif that is essential for many proteins involved the ubiquitination pathway. DTX3L (Deltex-3-like), also known as BBAP, is a 740 amino acid protein that is similar to Deltex-3 and acts as a ubiquitin ligase in vitro. DTX3L can heterodimerize with Deltex-1, a transcriptional regulator, thereby enhancing the activity of the E3 ubiquitin ligase complex and increasing the influence of E3 on the Notch signaling pathway.
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