Product overview Description Anti-TNNI3 rabbit polyclonal antibody
Applications ELISA, WB
Immunogen Fusion protein of human TNNI3
Reactivity Human, Mouse, Rat
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol TNNI3
Full name troponin I type 3 (cardiac)
Synonyms CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
Swissprot P19429
Target Background Troponin I (TnI), along with troponin T (nT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).